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File 1                   File2
Col 1  Col2  Col3 Col4   Col 1  Col2  Col3 Col4
 1      2     3    4      4      3     2    1 
...
Line 4: # F1, L4,Cols 2, 3 & 4 match  F2, L2, Cols 2, 3 & 4
         #  and also matches contents of F2, L4, Col3 
         #  Do both satisfy your criteria?