Doozer:

A cheap & cheezy way you can do it:

$ cat t.pl
#!/usr/bin/perl
use 5.14.0;
use warnings;
use autodie;

#START
# Ignore first few lines (read & discard)
my $start=2;
<DATA> for 1..$start;
#END

# Process file...
while (<DATA>) {
    print;
}

__DATA__
Now is the time
for all good men
to come to the aid
of their party.

$ perl t.pl
to come to the aid
of their party.
[download]

Just add the lines between START and END to your program after opening your file. That way, it'll just discard the first $start lines before processing the remainder of the file.

As an added bonus, you can also:

• Make the $start parameter a command-line argument.
• Add another argument to limit the number of lines processed.

This lets you fire off multiple jobs that can run in parallel:

$ perl www_whacker.pl --start 200000 --limit 100000 >out1 &
$ perl www_whacker.pl --start 300000 --limit 100000 >out2 &
$ perl www_whacker.pl --start 400000 --limit 100000 >out3 &
$ # wait for all jobs to complete, then you can join all
$ # the results together:
$ cat out1 out2 out3 >output
[download]

...roboticus

When your only tool is a hammer, all problems look like your thumb.