Yes. The easiest way is to add this to the top of your Perl script that uses the module:

use lib '/home/foo';
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This will tell perl to look in /home/foo for modules.

Another option is to use the -I flag on your #!/path/perl line:

#!/usr/local/bin/perl -w -I/home/foo
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A final option is to set the PERL5LIB environment variable to the path.

Personally, I'd recommend using the first option (use lib).

If you're trying to *install* modules into your home directory, run Makefile.PL with the PREFIX option:

perl Makefile.PL PREFIX=/home/foo
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And if you're using CPAN.pm, specify PREFIX=/home/foo as the argument to Makefile.PL in the configuration options when you first run the shell.