Yes, you can open a file handle for output or input against a string for instance:

my $variable = "HELLO world\nhow are you?\n";
open(my $fh, '<', \$variable);
print $_ for (<$fh>);
[download]

Prints:

HELLO world
how are you?
[download]

Although this wont work if the CPAN module only takes a filename, but usually modules that take a filename will also accept a file handle like the one created above.