in reply to Re^6: Problem Writing to FTDI COM Port using Win32::FTDI::FTD2XX
in thread Problem Writing to FTDI COM Port using Win32::FTDI::FTD2XX

What's "OpenDevByIndex" ? Typo? I don't see any such method. Assuming it's a typo, does $FTDIdev->OpenByIndex(1) return 1? Did you try turning on PFT_DEBUG?
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Re^8: Problem Writing to FTDI COM Port using Win32::FTDI::FTD2XX
by PrfrrdUsrNm (Initiate) on Jan 20, 2014 at 05:12 UTC

    Sorry typo, was correct in code.

    Found a way to use the rts lines, simplifies the solution to a single port.

    Thanks for the help.