Firstly, please put your error output in <code>...</code> tags. Does what you've posted there look the same as the error message you received?

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The input data you described looks nothing like what you're reading. Did you open the correct file?

The data you've read into $line starts off something like (my best guess at reconstructing it):

 144 x Lcb (P CAL_LCBMS [CAL_LCBMS] T lcb I [ACT=-, NCLK=chpl::ec0+clk
+, ...
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That (along with all the text that follows it) contains many characters that have special meanings within a regex. A character class is specified within square brackets (i.e. [...]). The "[ACT=-," part of $line starts a character class which includes all the charcters in the range "=-,"; however, ord('=') == 61 and ord(',') == 44, so the start of that range is after its end and, therefore, invalid.

That explains the error which would have looked something like:

Invalid [] range "=-," in regex; marked by <-- HERE in
    m/ 144 x Lcb (P CAL_LCBMS [CAL_LCBMS] T lcb I [ACT=-, <-- HERE ...
[download]

While I suspect this is a mistake on your part (e.g. you're reading the wrong file), if you want to interpolate data like that into a regex, you'll need to do something like:

/\Q$line/
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See quotemeta for details.