I added the line Include /etc/apache/httpd.conf.local at the end of my /etc/apache/httpd.conf and my /etc/apache/httpd.conf.local looks like:

 
SetEnv ORACLE_BASE=/usr/lib/oracle
SetEnv ORACLE_HOME=/usr/lib/oracle/12.1/client
SetEnv LD_LIBRARY_PATH=/usr/lib/mpi/gcc/openmpi/lib:/usr/lib/oracle/12
+.1/client/lib
SetEnv TNS_ADMIN=/usr/lib/oracle/12.1/client
SetEnv PATH=/usr/lib/oracle/12.1/client:$PATH
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and everything workes fine after retsarting ...