Generally and generically speaking, I would recommend that “you should use the interpreter that is most-native to your particular operating system, which should be the one that is most-native to your hardware.”   If you are running a modern-day 64-bit microprocessor, you (so to speak ...) “owe it to that microprocessor” to be running an OS that expects what it can give.   And, in such an environment, you should run an application that is truly designed for it.

“Naturally, there are exceptions,” and an entirely-justifiable example of such an exception would be a legacy library that is mission-critical but that has not yet caught up with the 21st Century.   You would perhaps consent to run a 32-bit interpreter for this compelling reason alone.   But you would be anxious for the inevitable future, panting for the day when it finally arrives.