If in your situation I'd go for Prima because it seems to me a valid, modern and maintained set of modules.

In my real experience I only have Tk as tool and I subscribe what zentara said in in praise of poor old Tk but there are precisations to be made. What follows is my personal understanding of the Perl GUI panorama in 2020.

Tk is a port of the tcl but the author has problems to fix issues and to incorporate new features of the tcl language. My warmest thanks to him for all his work. Tk is solid and works: if some little thing does not work, it will never work.

I can add from my experience that perlmonks is the last place in the planet where some Tk wisdom is conserved.

Then there is Tkx which is a tiny layer on top of Tcl that allows Tk based applications to be written in Perl: it is well maintained and you can expect every new feature to be available.

Tcl::Tk module by other hand provides access to the Tk library within Tcl/Tk installation.

Re: How to build a scrabble type of game with perl is also interesting and a bounch of links in my bibliotheca

L*