It looks to me like the pieces of code relating to $process_file and $process_file2 are basically identical, which means you can simply do the same thing in a loop. Note you've got a stray . on the second-to-last line of your code, and the multiple close $process_file statements don't make sense, as those variables hold the file names, not handles.

for my $process_file ($rrconfig::locodata, $rrconfig::availlocodata) {
    open(my $data_file_handle, '<', $process_file) or die("$process_fi
+le: $!");
    my @data = <$data_file_handle>;
    close($data_file_handle);
    chomp(@data);
    open(my $out_file_handle, '>', $process_file) or die("$process_fil
+e: $!");
    foreach my $line_from_file ( @data ) {
        my @field = split( /\:/, $line_from_file );
        next if( ($field[1] eq $delroad) && ($field[2] == $delnumber) 
+);
        print $out_file_handle $line_from_file, "\n";
    }
    close $out_file_handle;
}
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Although I feel like I've been plugging it pretty often lately, note this code can be simplified using inplace editing, using either $^I (an example, but note that -i has a few caveats like in some cases only issuing a warning when something goes wrong, instead of dying), or my module File::Replace. This has the advantage of not having to load the entire file into memory, like the code above does.

use File::Replace 'replace3';

for my $process_file ($rrconfig::locodata, $rrconfig::availlocodata) {
    my ($infh, $outfh, $repl) = replace3($process_file);
    while ( my $line = <$infh> ) {
        chomp($line);
        my @field = split( /\:/, $line );
        next if ($field[1] eq $delroad) && ($field[2] == $delnumber);
        print $outfh $line, "\n";
    }
    $repl->finish;
}
[download]