Here is another solution for you.
This could be made more general purpose, but...

use strict;
use warnings;
use Inline::Files;


my @files = qw (FOO BAR FOOBAR MOREFOO);

omit_lines(\@files, 5, 42);


sub omit_lines 
{
   my ($files, @nums) = @_;  
      
   foreach my $fileName (@$files)
   {
      print "*** $fileName ***\n";
      while (<$fileName>)
      {
         next unless /^\S/; #skip blank lines
         my (@digits) = $_ =~ /(\d+)/g;

         next if (     ($digits[0] == $nums[0]) 
                   and ($digits[1] == $nums[1])
                 );
         print;
      }
   }
}

=prints:
The lines with 5, 42 are gone..

*** FOO ***
abc 1 32
*** BAR ***
asdf 2   12
*** FOOBAR ***
xyz 3 43
*** MOREFOO ***
abc 1 32
xyz 3 43
=cut



__FOO__
abc 1 32

__BAR__
asdf 5    42
asdf 2   12

__FOOBAR__
xyz 3 43
asdf 5     42

__MOREFOO__
abc 1 32
asdf 5   42
xyz 3 43
asdf 5          42
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