My machine at work has had an SSD for about 2 years with no issues and much improved speed (I'm mainly running AutoCAD on it, and Perl, of course :-) ). I also have two laptops at home with SSDs. One is old, has had only an SSD in it for about 3 years, and runs Linux. The other is less than a year old with an SSD and an HDD, and I dual-boot Linux and Windows on that. So far, performance and reliability has not been an issue on any of it. The only frustrating part for me was getting Windows set up across the two hard drives so that all my data would be on the HDD; it's not a straightforward and trivial process (especially if you want backups and encryption to work properly). Linux, of course, was a piece of cake in that respect.

Here's a link to a discussion on answers.microsoft.com that discusses some of the issues involved in moving the user's data directory to another hard drive. Note, especially, some of the comments below the main answer.