NOT to annoy you by remarking on the obvious -- but it sounds as though you're pretty irritated as well as frustrated.

Nonetheless, we DO need more info to be helpful... so slow down, take a deep breath, and we WILL help. We can see from your other posts that you'll have no great problems following this sketch of (detailed) info we'll need... I at least, know of no reason for Win8 to balk at your project (Tk might be a different matter, but we'll leave that to another responder).

• Specifically, WHAT is your script telling Perl about how it's to proceed? Please cut and paste the use... ; lines from your code. Two of them should be on the order of use Win32::Gui...; and use Tk ...;
• That leads to a second question: Did you install Win32::GUI? If so, how (details!) (<UPDATE 2>:
  • Are you aware that it was NOT a core module at least thru 5.016 and perhaps later and is not found in the Active State repo for 5.018 and, at its SourceForge project homepage. this information:

    Latest Release
    The latest release is v1.06, and was released on February 13th, 2008. ### DANGER!
    ...[Source][ActivePerl 5.6 PPM] [ActivePerl 5.8 PPM]  [ActivePerl 5.10 PPM]

  suggests the package may not be under active development? </UPDATE 2>>
• Ditto, re Tk
• What Perl version are you using? Which Win32::GUI version? Which Tk?

There are many Monks here who'll be ready and willing to lend assistance with this kind of info. If I've forgotten some you're asked for later, consider these my alibis:

• On asking for help
• How do I post a question effectively?

And, of course, if you can boil your code down to 10 or 15 lines whose execution produces the same failures that have bothered you previously, pray post that code!

Update 1: typo fix, word choice improved(s/commenting on/remarking on/;)