I have installed the Perl 5.28 which incudes Tk modules as builtin module from below URL. https://platform.activestate.com/vinothree/ActivePerl-5.28/distributions

When I start using the Tk module with perl 5.28 I get below error,

Event.c: loadable library and perl binaries are mismatched (got handsh
+ake key 00000008000004B0, needed 0000000000000000)
[download]

C:\Users\VinothG>perl -V
Summary of my perl5 (revision 5 version 28 subversion 1) configuration
+:

  Platform:
    osname=MSWin32
    osvers=10.0.14393
    archname=MSWin32-x64-multi-thread
    uname=''
    config_args='undef'
    hint=recommended
    useposix=true
    d_sigaction=undef
    useithreads=define
    usemultiplicity=define
    use64bitint=define
    use64bitall=undef
    uselongdouble=undef
    usemymalloc=n
    default_inc_excludes_dot=define
    bincompat5005=undef
  Compiler:
    cc='undef'
    ccflags =' -s -O2 -DWIN32 -DWIN64 -DCONSERVATIVE -DPERL_TEXTMODE_S
+CRIPTS -DUSE_SITECUSTOMIZE -DPERL_IMPLICIT_CONTEXT -DPERL_IMPLICIT_SY
+S -fwrapv -fno-strict-aliasing -mms-bitfields'
    optimize='-s -O2'
    cppflags='-DWIN32'
    ccversion=''
    gccversion='4.6.3'
    gccosandvers=''
    intsize=4
    longsize=4
    ptrsize=8
    doublesize=8
    byteorder=12345678
    doublekind=3
    d_longlong=define
    longlongsize=8
    d_longdbl=define
    longdblsize=16
    longdblkind=3
    ivtype='long long'
    ivsize=8
    nvtype='double'
    nvsize=8
    Off_t='long long'
    lseeksize=8
    alignbytes=8
    prototype=define
  Linker and Libraries:
    ld='undef'
    ldflags ='-s -static-libgcc -static-libstdc++ -L"C:\Perl64\lib\COR
+E" -L"C:\MinGW\x86_64-w64-mingw32\lib"'
    libpth=C:\MinGW\x86_64-w64-mingw32\lib
    libs=-lmoldname -lkernel32 -luser32 -lgdi32 -lwinspool -lcomdlg32 
+-ladvapi32 -lshell32 -lole32 -loleaut32 -lnetapi32 -luuid -lws2_32 -l
+mpr -lwinmm -lversion -lodbc32 -lodbccp32 -lcomctl32
    perllibs=-lmoldname -lkernel32 -luser32 -lgdi32 -lwinspool -lcomdl
+g32 -ladvapi32 -lshell32 -lole32 -loleaut32 -lnetapi32 -luuid -lws2_3
+2 -lmpr -lwinmm -lversion -lodbc32 -lodbccp32 -lcomctl32
    libc=
    so=dll
    useshrplib=true
    libperl=libperl528.a
    gnulibc_version=''
  Dynamic Linking:
    dlsrc=dl_win32.xs
    dlext=dll
    d_dlsymun=undef
    ccdlflags=' '
    cccdlflags=' '
    lddlflags='-mdll -s -static-libgcc -static-libstdc++ -L"C:\Perl64\
+lib\CORE" -L"C:\MinGW\x86_64-w64-mingw32\lib"'


Characteristics of this binary (from libperl):
  Compile-time options:
    HAS_TIMES
    HAVE_INTERP_INTERN
    MULTIPLICITY
    PERLIO_LAYERS
    PERL_COPY_ON_WRITE
    PERL_DONT_CREATE_GVSV
    PERL_IMPLICIT_CONTEXT
    PERL_IMPLICIT_SYS
    PERL_MALLOC_WRAP
    PERL_OP_PARENT
    PERL_PRESERVE_IVUV
    USE_64_BIT_INT
    USE_ITHREADS
    USE_LARGE_FILES
    USE_LOCALE
    USE_LOCALE_COLLATE
    USE_LOCALE_CTYPE
    USE_LOCALE_NUMERIC
    USE_LOCALE_TIME
    USE_PERLIO
    USE_PERL_ATOF
    USE_SITECUSTOMIZE
  Locally applied patches:
    ActivePerl Build 0000 [25391a6d]
  Built under MSWin32
  Compiled at Oct 28 2020 18:24:51
[download]

Looks like either you're picking something up from another/old installation (check PERL5LIB and PERL_LOCAL_LIB_ROOT) or they made a mistake when building this perl for you. Nobody else can access that URL, you could consider contacting AS support, since you're using their services.

Interesting. I got an email from AS related to my custom 5.26 build with Tk:

"Please note, the Platform is in Beta. So if you have any issues with a custom runtime or can’t find a package, let us know and we can take a look!

Happy coding,
- The ActiveState Team"

If there are issues, I would take AS up on that offer!
This custom build stuff is a huge new feature for AS and I am sure that there are some hiccups. That's part of the reason that I am still at v5.24.

Update: There is some version level where AS said that installing a later version over a previous version was "safe". I don't remember when that was. I would uninstall any AS Perl versions. Then install v5.28 anew and see how that works?