Are you talking from the perspective of writing CPAN distributions, or simply a user of the Perl language writing scripts for your own use?

For the former, I definitely try to minimize my use of external dependencies where possible and practical. As a user though, I don't care whatsoever. Whatever makes my job easier to get the results I want from the script I'm writing dependably, I use whatever is available. I don't care if things have to be compiled or not. Several of my own CPAN distributions are C/C++/XS based, for various reasons (speed is but a single one of them).

With the likes of perlbrew/berrybrew, adding/removing/changing perls and modules is trivial, and has no effect on system components whatsoever. At least with berrybrew (unsure in perlbrew), you can simply copy a full blown Perl installation to another system by copying a folder, and voila, it works just dandy with no recompilation needed at all (in fact, that's my next update to the software... an import/export feature to do exactly that, instead of the manual process it is now).