in reply to Re^4: Perl threads loss of performance with system call
in thread Perl threads loss of performance with system call

Probably it matters. From ibidem:

«Perl Bindings...The RNA module to access RNAlib C-library functions from within Perl scripts»

I understand this like this: You don’t need to shell-out. You can do the stuff in pure Perl. If you fork or use threads is your design decision.

Update: See here

«The Crux of the Biscuit is the Apostrophe»

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Re^6: Perl threads loss of performance with system call
by daniel85 (Novice) on Jul 14, 2021 at 20:45 UTC
    I am sorry, but it is not like this. Not every single part of the framework is accessible from the Perl bindings. Ergo, the need to access it via shell-out.

      Too bad 🤪😎. Is it better in Python? As there is Inline::Python.

      «The Crux of the Biscuit is the Apostrophe»