in reply to Need help with IPC::run3

Encoding: wave" Audio Source: E:\Temp\Greatest Audio Destination: nul"

That makes it seem like a quoting issue I think. Unfortunately that's a nontrivial issue on Windows since, unlike *NIX, the command being called could be at fault too. Could you make sure you have the latest versions of IPC::Run3 and Win32::ShellQuote installed, and set the environment variable IPCRUN3DEBUG=1 and report the output of that?