As i've said before in Re^2: Unrecognized ICU conversion error and kcott explained much better in Re^4: Unrecognized ICU conversion error [after your updates], your problems seem to stem from bugs in your perl scripts (improper unicode handling), not from the Perl interpreter itself. There simply is "no high level configuration" to work around the bugs in your software.

There are basically three ways to fix the problems with your code:

1. Fix the bugs yourself.
2. Contact whoever wrote the code to have them fix it.
3. Open Source the whole thing and hope it is useful enough to someone that they spend their spare time to fix your code for free.

Short of that, you could just make sure that no Unicode enters your system in the first place.