To bookend this whole thing, I want to say that I would stay away from the DHT* type sensors.

For almost 10 years, I had a significantly nice multi-stage indoor cannabis growing operation that I used them for to help me with my fully automated hydroponic system.

This is but my personal experience. Not only had I written software against them for the Pi, I also have software that I wrote for my real controllers, little Node MCU units, particularly the ESP-8266 and its derivatives (I still use frequently my WeMOS D1 Mini units). The DHT units required a lot of averaging and mediating of numbers to ensure a correct result. I learned by using them though. I learned a lot about math. Monks here taught me about "filtered moving average" and "probability normalization" and such. That's a fun game, literally, until I just want to code more.

I don't like to give advice unless asked, but I would say that instead of the DHT* units, based on my experience with the difficulties they presented me, it may be prudent to investigate other options on hardware for the rather delicate situation** that faces you.

-stevieb

** Inserting devices and custom software into your HVAC may influence how your insurance company looks at you, so I would definitely consider this as delicate.