An advantage of the MSI version is that it is on the %PATH% after installation, without any portableshell.bat invocation. I have several versions of portable Strawberry (including the awesome PDL-enabled distribution), but when I run other programs which start Perl it is good to have a fallback which is "always there".
Concrete example: I often start Emacs before running any shell. In Emacs, I can read nicely rendered POD, but that needs perl and pod2html on the path.
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