Just like you would from the commandline

perl -Iwhatever -Iwhateverelse -f programfile.pl -- args args args
[download]

http://sourceforge.net/p/citrusperl/code/HEAD/tree/tags/PRE_VERSION_2001/execsrc/main.c#l79

https://metacpan.org/source/PLAVEN/Padre-1.00/win32/padre.c

env manipulation par_unsetenv("PERL5OPT"); https://metacpan.org/source/RSCHUPP/PAR-Packer-1.025/myldr/utils.c / https://metacpan.org/source/RSCHUPP/PAR-Packer-1.025/myldr/mktmpdir.c

And here it is runperl.exe by another nameperl scripts executor on Win32, and its cousin Turn your script into binary without a compiler! :-P