RichardK a big thank you! It works! and the code is below:

sub handler {

my $timer = $mw->repeat(100,\&sighandler );

sub sighandler {

my $data = $port->lookfor;
return unless $data;
# do stuff
print STDOUT "$time Message Received: (" . $data . ")\n";

if ($data =~ /OF/) {
$signalblock100->configure(-image => $mw->Photo(-file => 'picture.jpg'
+));
}
$port->lookclear;
}

}
[download]

Had to use a sub with in a sub...unless there is a different way to do it..the code works as follow:
1.) Button is Pushed = LEDs turn on for 8 seconds
2.) LEDs go out and the word OF is sent from the Arduino and is Polled by the Perl Script and the button that is shaded is now unshaded and the RX/TX buffers have been purged. Thanks again!