I would put the mapping rules in another spreadsheet something like this

#!perl
use strict;
use Win32::OLE::Const 'Microsoft Excel';
Win32::OLE->Option(Warn => 3);

my $ex = Win32::OLE->GetActiveObject('Excel.Application')
        || Win32::OLE->new('Excel.Application', 'Quit');

my $wb1 = $ex->Workbooks->Open("c:\\temp\\Book1.xlsx") ; 
my $wb2 = $ex->Workbooks->Add ; 
my $wb3 = $ex->Workbooks->Open("c:\\temp\\Mapping.xlsx");

my $sht1 = $wb1->Worksheets("Sheet1");
my $sht2 = $wb2->Worksheets("Sheet1");
my $sht3 = $wb3->Worksheets("Sheet1");
my $lastRow = $sht3->UsedRange->Find({What=>"*",
    SearchDirection=>xlPrevious,
    SearchOrder=>xlByRows})->{Row};

# Copy columns
for my $n (1..$lastRow){
  my $in  = $sht3->Range("A$n")->Value;
  my $out = $sht3->Range("B$n")->Value;
  print "Mapping rule $n : $in => $out\n";
  $sht1->Range("$in:$in")->Copy( $sht2->Range("$out:$out") );
}

$wb2->SaveAs("c:\\temp\\Book2.xlsx");
undef $ex;
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