You should be able to get:

my $fields = $perl->{issues}[0]{fields};
# Now you can get
my $customfield_22181     = $fields->{customfield_22181}; # Should get
+ you the desired 'Jira Testing'
my $customfield_11150_val = $fields->{customfield_11150}{value}; # Sho
+uld be  'Yes' 
my @weekdays              = map {$_->{value}} @{ $fields->{customfield
+_11780} };
[download]

Note : customfield_11780 should be an array of hashes .. the dump formatting does not make this clear.

You use <pre> tags where you should have used <code> tags.

Untested.
Update:Changed $perl{ to $perl->{