I do not really want to bash Windows installations, but the sensible thing to do would be to bite the bullet and use Linux (without losing your Windows, of course):

Option 1:

Install Virtualbox on your windows, and download a virtualbox Bio image, ready to use.

Option2:

Download Bio-Linux DVD, and boot from USBstick or DVD. There everything "just works" (albeit a bit old now, as the image is 2 years old by now. It still works out of the box)

(you can combine those, but installing your own Linux in virtualbox might be a bit more challenging, I guess you just want it working, and not fiddle with Linux...)

ps: I run Debian, and the cpan command to install the libraries worked.