I use a combination of procmail with my own and the SpamBouncer recipe set which filters everything into folders (direct-to-me, mailing lists, and possible and most likely spam); I typically read everything that I accept but still peruse the possible spam folders because there's enough people that contact me for spam-haven-ISPs that I need to follow up on those.

Of course, I've been having a much easier time with spam since I've started using weak-munging of my email and use of forwarding addresses on my email server. Most people that contact me often know the right address to use; everything else that comes in as spam is on one of the munged-addresses.

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Dr. Michael K. Neylon - mneylon-pm@masemware.com || "You've left the lens cap of your mind on again, Pinky" - The Brain
It's not what you know, but knowing how to find it if you don't know that's important