On some platforms things are shipped without large file support, you should be able to see it listed in the output of perl -V, for example:

Characteristics of this binary (from libperl):
  Compile-time options: HAS_TIMES HAVE_INTERP_INTERN MULTIPLICITY
                        PERLIO_LAYERS PERL_DONT_CREATE_GVSV
                        PERL_HASH_FUNC_ONE_AT_A_TIME_HARD
                        PERL_IMPLICIT_CONTEXT PERL_IMPLICIT_SYS
                        PERL_MALLOC_WRAP PERL_NEW_COPY_ON_WRITE
                        PERL_PRESERVE_IVUV USE_64_BIT_INT USE_ITHREADS
                        USE_LARGE_FILES USE_LOCALE USE_LOCALE_COLLATE
                        USE_LOCALE_CTYPE USE_LOCALE_NUMERIC USE_PERLIO
                        USE_PERL_ATOF
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See also: http://search.cpan.org/~shay/perl-5.24.1/INSTALL#Large_file_support