I never have gotten Padre to work on any platform. On those occasions when I want an IDE debugger, I find that the ptkdb sets up right from CPAN very nicely and works.

I have used Komodo and DDD in the past as well, but ptkdb is simple to use and provides what I need without having to set up another full application. It does require Perl::TK, but that installs as a dependency pretty smoothly in my experience. Once installed, it is a matter calling perl -d:ptkdb (script_name)

Hope that helps.