I adore Catalyst. Try out all the major frameworks before making a major choice. You might find one of the others to your liking. Catalyst has very good testing utilities, for example… Mojo’s is probably better/easier. You might also read some of the email threads from the various lists to see which community seems like the best fit.

I've played around with Dancer (ie got a Hello World template view up and running) and did a little more in Mojo, but from what I've read so far, the learning curve of Catalyst is far worth it. I agree with the sentiment that it's difficult to learn all three (or more) frameworks enough to make an informed decision, but I dabbled, and it seems like Catalyst is the way to go, especially since my grand plans for this project include potentially thousands of updates per hour, with the potential of hundreds of thousands of records. With that in mind, it seems Catalyst is the clear winner if only based on project size. (Again, this is all based on what I've read/heard.)

Thanks a lot for your input, I appreciate the time and feedback!