Yes you can do that.

But to do that in a sensible way, please learn about the data structures that Perl offers and also read the DBI documentation.

->execute takes a list, not a comma-separated string. So, instead of building a comma-separated string, which still has the same interpolation problems, use an array to collect the changed fields.

Also, it seems you are reinventing your own ORM. You might want to take a look at DBIx::Class or Class::DBI instead.