Honestly, I once used Win32::GuiTest a long long time ago for such a purpose. I had my main loop listening to the keypresses until the appropriate sequence occurs then call the functions. It behaved like a keylogger which IMO is highly suspicious.

Then I rewrote the script into AutoIt because it had HotKeySet function.

However, when I got stuck with AutoIt's GUI, I decided to stick with Perl for good.