Hard to tell with just this info. You could, for example, be leaking file descriptors and hit the open file limit. It might be helpful to try something like this to get more info:

# wrap the call that's bombing
eval {
     require ModuleThatsFailing;
};
my $err = $@;
if ($err){
  # add whatever other debugging/info you want
  die("err: [$err] errno [$!]");
}
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