I found an easy way to experiment with it. Use Moo::sification as an indicator:

#! /usr/bin/perl
use warnings;
use strict;
use feature qw{ say };
#use Local;

{   package My;
    use Moo;
    has x => (is => 'rw');
}
my $o = 'My'->new(x => 12);

#say for $o->meta->get_method_list;
#say $o->meta->isa('Moose::Meta::Class');
require Moo::sification;
Moo::sification->unimport();
[download]

where Local uses Moose.

Uncommenting either the use Local or any of the ->meta lines makes the unimport fail with

Can't disable Moo::sification after inflation has been done
[download]