I work on Windows using latest ActiveTcl (only 64 bit available), Tcl::pTk (to have access to Tk from Perl), and Strawberry Perl (64bit). The combination works fine. Just be sure to have Perl 64 bit installed, then install Tcl::pTk (this will install also Tcl.pm which is the linking part between Perl and Tk). The advantage of Tcl::pTk over Tkx is that is actively maintained, as is Tcl/Tk.