Since 5.6, Perl can be compiled with large file support. Unfortunately, you'll probably have to be the one to compile it. Type 'perl -V' at the command line and look for "uselargefiles=" in the output. If it's "yes", you're in business. If not, you're in for a compile. :)
I'm on a win32 machine however and the solution you offered seems to only be valid for unix stations. I downloaded the uncompiled code and only came across that flag in non win32 makefiles