Not having used the Perl GUI interfaces much, I can't speak to that aspect, but I have used Perl to work with an Access database and have had success with that (see Web Deployment Schemes). The Win32::ODBC module is very easy to use.

But if this running on one box and is only going to be accessed through that box, I would consider doing the programming in Access itself using VBA. By programming in access, you can easily incorporate the native forms, queries, reports, etc. into the application. I'd rather code just about anything in Perl than using VB/VBA, but this could be an instance where you could get away with creating a series of forms without having to do a lot of coding behind it.