I don't think so. I don't think that DBI interfaces
to SQL*Plus therefore SQL*Plus commands like ...
edit, spool, set pagesize etc ... would just been seen
as bad sql statements.


But if you wanted to exec SQL*Plus commands from perl you
could try something like this ...

open SQLPLUS, "sqlplus whatever/whoknows@somewhere|";
print SQLPLUS << COMMANDS;
set pageszie 1000
spool myfile
desc myTable
select blah from myTable
/
spool off
/
COMMANDS
[download]

... beware that the above is off the top of my head
and I am not 100% sure that you can cut-n-paste it
and have it run. I hope that some version of te above
snippet can point you in the right direction.