I would suspect that the only issue with perl modules is if the modules use static linking of zlib. Because the zlib bug is simply fixed by installing the corrected version, which has no API changes, modules with XS extension that dynamically link against zlib should be fixed when zlib is fixed.

The zlib bug is more of a hit to those that have static zlib linking. These need to be recompiled to be fixed, which can be more of a hassle as these programs tend to be larger (like the kernel or Mozilla).

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Dr. Michael K. Neylon - mneylon-pm@masemware.com || "You've left the lens cap of your mind on again, Pinky" - The Brain
"I can see my house from here!"
It's not what you know, but knowing how to find it if you don't know that's important