There are no built in limitations in Perl that should be causing your problem. However it is difficult to determine what exactly is going wrong with out looking at the code and maybe an example of the text file it is reading. You should consider posting the code that is giving you problems and we should be able to help you more.
Also you should read
Before you post.. to get a better understanding of how to ask for help and what will give you the best response.
-Prime
Update: You should also consider changing the title to something that is more descriptive of your problem.