in reply to Does anyone have a list of 'donts' when optimizing?
To optimise you need to identify where the time is spent. The most useful tool is Devel::DProf which will detail the percentage of time spent in each section of your code. You are wasting your time doubling the speed of a part of code that only takes up 1% of the total runtime. On the other hand a small improvement in bottleneck areas will reap large benefits. Assuming you have a 'normal' database driven website consider:
Often perlcode per say is not the bottleneck. You can't effectively optimise unless you identify where it is worth investing the effort.
cheers
tachyon
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