No, it is not possible. Safe.pm does not allow for XS modules to be loaded, only pure Perl modules can be loaded. The only way of making XS modules like Data::Dumper work, is by pre-loading them and sharing the symbol table. use them inside of the compartment's package to import the symbols to the right place.

use Safe;
my $safe = Safe->new('Safe::Compartment');
$safe->permit(Opcode::full_opset);
for my $module (qw/Data::Dumper/) {
    (my $file = "$module.pm") =~ s!::!/!g;
    $safe->share('*' . $module . '::');
    package Safe::Compartment;
        require $file;
        $module->import();
}
$safe->reval(qq{
    use Data::Dumper;               # Already done, so not needed.
    print Dumper([ 1..10 ]), "\n";
});
warn $@ if $@;
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This doesn't work well if the module has more namespaces.

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