Hopefully UltraEdit will save things with linefeeds and not carriage returns, otherwise scary to me. Visual Studio can use a plugin from Activestate.com for a visual perl dev environment. Or maybe better yet check out their Komodo IDE. Whatever editor, you should look for one that has a Perl mode that does indenting and syntax coloring. If you can collapse functions even better.

I use Xemacs on linux. There is an NT version too, or you can run the text-mode emacs client in a cygwin shell locally.

So as not to start a holy war, there are also vi and vim which like the emacs can be accessed remotely, which is probably how most config file tweaking is actually done.

Update:I confess, after thinking about it I probably do most quick config edits in vi. Eeek! Whodaknown?