in reply to perl development OS of choice
If you have a spare machine, I'd start gradually, learning one desktop app at a time as you need to. The order I learnt them in was:
If you try and do everything at once, I think you might get a little overwhelmed - so start gradually if you can.
You'll probably need to keep a Windows box in some form to test web pages in IE, whatever you do...
Just my .02
cLive ;-)
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