Open the file (possibly in binmode if you have a silly platform), read in chunks of data (make sure you are reading in chucks that are a multiple of 4 bytes) - either with sysread, or just <> (for the latter, set $/ to a reference to the amount of bytes you want to read), and use unpack to translate the raw bytes to integers.

Here's an example:

#!/usr/bin/perl

use strict;
use warnings 'all';

open my $fh => "< /tmp/foo" or die $!;

$/ = \100;

while (<$fh>) {
    my @nums = unpack "L*" => $_;
    print "@nums\n";
}
 
close $fh;  
 
__END__
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Note that I used L in the unpack routine. This is garanteed to be exactly 32 bits, unlike I which is at least 32 bits.

Abigail