I did posting to ptk mailing list, and got a reply from Slaven Rezic, he noticed that sub became faster by 20-30%.

But then after that I did some experiments and realized that 'Ev' sub is usually used in startup and binding time, therefore it is not critical, because it is usually *not* used inside events callbacks.

Anyway, I keep my slightly faster version of 'sub Ev' in my own VK::TkOverrides package which contain some functions to override from Tk that I think I need to fix :)

Courage, the Cowardly Dog.
PS. Something fishy is going on there, or my name is Vadim Konovalov. And it's not.