The DBI documentation indicates that "When trying to insert long or binary values, placeholders should be used since there are often limits on the maximum size of an INSERT statement..."

So maybe you could try something like this:

$sth = $dbh->prepare(q{INSERT INTO table (BigChunk) VALUES (?)});
$sth->execute( $big_chunk );
[download]

I can't try this here, but give it a go and see if it works.

~CubicSpline
"No one tosses a Dwarf!"