Well I went ahead and asked on the wxPerl mailing list, and this is what I got.

Probably it should (because it DWIMs, and it is easier than what is below).
For now:
$frame->Disconnect( 123, -1, &Wx::wxEVT_COMMAND_MENU_SELECTED );

If you need to disconnect other events, just look in lib/Wx/Event.pm
for the definition, replace ->Connect with ->Disconnect and remove the
last argument (the code reference).

> Is it even possible? (i suspect it's not, but I can't be sure) 
It is :-)
 
HTH
Mattia

Well that works (kickass!), but I can't wait until it DWIM's as well ;)

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