So this would be a very open method:

#!/usr/bin/perl
use strict;
use warnings;

my $base = shift or die;
my $cmpdepth = 2;
my %base = ();

{
  open my $fh ,'<',$base or die "opening '$base' failed: $!";
  while(defined(local $_=<$fh>)){chomp;
     my $c = \%base;
     for(split){
       $c = ($c->{$_} = {});
     }
  }
  close $fh;
}

while(defined(local $_ =<>)){chomp;
  my @s = split;
  my $f = 1;
  my $c = \%base;
  for( 0 .. ($cmpdepth - 1) ){
     $f-- and last unless
      exists $c->{ $s[$_] } and $c = $c->{$s[$_]};
  }
  print "$_\n" if $f;
}
[download]

that gives the possibility to check up to any number of fields.

while(defined(local $_=<$fh>)){chomp;

Why do you write it that way? That is, why localize $_, and why test for defined when the line read can only be false at EOF?

That's just while(<HANDLE>) with localized $_, I prefer it, although it's not neccessary in that script.

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