I'm not quite clear on what you're trying to do, but you can certainly use Perl to automate Word and Excel - check out the Win32::OLE module that comes with ActivePerl. I have done this sort of thing from Perl in ASP pages but beware, bugs in your code can result in winword.exe and excel.exe processes left running on the server.

You can also use OLE to work with Access, but the recommended approach is to use DBI.