I find that Tk is very nice and a good fit with Perl. On the downside, documentation is hard to find, and it doesn't do everything that a native GUI can do on Windows. It's text control, OTOH, is awesome.

Before Tk was ready for prime time on Windows, I needed a simple GUI and used dynamic HTML. Basically, the application showed a list of things to do, and filled in results/notes on each as it did them, so it was a good fit for that kind of job. But that's what Perl is often used for -- duct tape or batch type jobs. Basically, this was a command-line program concept with a more end-user-friendly front end.